Earlier Native American inhabitants of the St. George area included the Virgin River Anasazi, who left evidence of their presence in the rock art and archaeological sites that remain. The first recorded Euro-Americans to visit the area were the Dominguez-Escalante Party in 1776; they were followed by fur trappers, including Jedediah Smith, and still later by government survey parties.
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By 1854 the LDS Church had established an Indian mission at Santa Clara, two miles north of the St. George Valley. In 1857 and 1858 experimental farms were set up to the east and west of where St. George was to be built. While touring the experimental desert farms in May 1861, Brigham Young predicted the settling of the area. Five months later, in October 1861, 309 families were called by church authorities to the what was called the Cotton Mission. Most of those sent had abilities that were deemed essential to establishing a successful community.
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When the Civil War broke out in 1861, Brigham Young thought it would be necessary to raise cotton, if possible. Many of the early settlers of St. George originally came from the southern states. They came to the "Cotton Mission" to grow cotton, but they also brought with them a phrase for the area which has become widely adopted--they called the St. George area "Utah's Dixie.
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St. George itself was named in honor of George A. Smith, who, although he did not participate in the town's settlement, had personally selected most of the company of the pioneers of 1861. The first years in the new outpost were difficult. Great rainstorms almost destroyed the farmlands, and intense summer heat and lack of culinary water made life far from pleasant. St. George Utah Lodging